817 Ethanol induces skin hyperpigmentation in mice with aldehyde dehydrogenase 2 deficiency
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چکیده
منابع مشابه
Aldehyde dehydrogenase and ethanol preference in mice.
The aldehyde dehydrogenases from livers of the inbred mouse strains C57BL/6J, DBA/ZJ, and the F1 generation of the cross between these strains (C57BL/6J X DBA/2 J) have been purified over 60-fold. Alcohol dehydrogenase activity is not present in the purified enzyme preparation. Enzyme preparations from both strains and from the F1 cross specifically require NAD but can oxidize a variety of alde...
متن کاملIncreased formation of gastric N(2)-ethylidene-2'-deoxyguanosine DNA adducts in aldehyde dehydrogenase-2 knockout mice treated with ethanol.
We analyzed an acetaldehyde-derived DNA adduct, N(2)-ethylidene-2'-deoxyguanosine (N(2)-Eti-dG) in stomach DNA of aldehyde dehydrogenase (Aldh)-2-knockout mice that were fed with alcohol to determine effects of alcohol consumption and Aldh2 genotype on the level of DNA damage in stomach. Aldh2-active(+/+), heterozygote(+/-) and knockout(-/-) mice were fed 20% ethanol for 5 weeks, then the level...
متن کاملTargeting aldehyde dehydrogenase 2: new therapeutic opportunities.
A family of detoxifying enzymes called aldehyde dehydrogenases (ALDHs) has been a subject of recent interest, as its role in detoxifying aldehydes that accumulate through metabolism and to which we are exposed from the environment has been elucidated. Although the human genome has 19 ALDH genes, one ALDH emerges as a particularly important enzyme in a variety of human pathologies. This ALDH, AL...
متن کاملExpression of Aldehyde Dehydrogenase 1 in Patients with Colorectal Cancer in North of Iran
Background and purpose: High cancer related mortality can be due to the presence of cancer stem cells (CSCs). Studies suggest aldehyde dehydrogenase (ALDH1) as a marker of CSCs. The aim of this study was to investigate its expression in colorectal cancer and also its association with clinicopathologic characteristics. Materials and methods: In a retrospective study, patients with colorectal ca...
متن کاملStructurally normal corneas in aldehyde dehydrogenase 3a1-deficient mice.
We have constructed an ALDH3a1 null mouse to investigate the role of this enzyme that comprises nearly one-half of the total water-soluble protein in the mouse corneal epithelium. ALDH3a1-deficient mice are viable and fertile, have a corneal epithelium with a water-soluble protein content approximately half that of wild-type mice, and contain no ALDH3a1 as determined by zymograms and immunoblot...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2019
ISSN: 0022-202X
DOI: 10.1016/j.jid.2019.03.893